Pre-implantation genetic diagnosis (PGD) using NGS

We provide fertility clinics with two types of tests for Pre-implantation Genetic Diagnosis (PGD), using the revolutionary NGS technique:

• Pre-implantation Genetic Screening (PGS) or PGD for aneuploidy (PGDa): it aims to identify alterations in embryo chromosome copy numbers (aneuploidy), which will endanger its viability during the implantation phase and in the early stages of gestation.
• PGD of monogenic diseases (PGDm): it aims to identify genetic alterations that have previously been identified in progenitors in embryos generated during an IVF cycle in order to determine those embryos that are mutation-free and hence prevent the disease from being passed on to offspring.

NGS technology offers the following advantages:

• Enables the simultaneous analysis of the 24 chromosomes with the highest resolution.
• Offers the possibility of carrying out studies into aneuploidy and monogenic diseases (caused by mutations in a single gene) separately or simultaneously in a single analysis.
• Reduced analysis time, becoming much faster and avoiding the need to freeze embryos while waiting for results.
• Enables a high number of samples to be analysed simultaneously.

• Assisted reproduction (IVF) clinics that require pre-implantation genetic diagnosis (PGT-A, PGT-M). In short, IVF centres that seek to offer their patients a high added-value service, increasing the success rate of the process.